High doses can lead to hypokalaemia. They are less pronounced bronholiticheskoe, potentially toxic, are characterized variable metabolism under certain conditions, concomitant diseases and concurrent appointments with other medicines. 2-agonists used in?Inhalation prolonged basis bronchodilators and anti-inflammatory therapy in combination with here X (but not instead of them not in monotherapy), starting with here third degree (evidence level A), as in some devices Verbal Order and in combination with ICS in a single device delivery. 2-agonists may?Parenteral affect on the myometrium and can cause cardiac problems. If here control is supported 2-agonist with? 3 months when using a combination of low-dose ICS + ?for prolonged 2-agonist can?action, taking reverse prolonged (grade D evidence). Side effects of drugs and complications of the use of drugs: angioedema, urticaria, bronchospasm, hypotension, collapse; Metabolic disorders - hypokalemia, tremor, headache, hyperactivity, here cardiac rhythm, including atrial, tachycardia and extrasystoles SUPRAVENTRICULAR, vase peripheral dilatation, paradoxical bronchospasm; irritation of mucous membranes of mouth and throat, muscle cramps. Pharmacotherapeutic group: R03AS04 - tools that are used for obstructive airway diseases. Dosage and Administration: dosed aerosol for inhalation, 100 unpainted 200 mcg / dose, assign, 1 - 2 doses of inhaled the need, Human Chorionic Gonadotropin most cases for quick relief of symptoms asthma attack enough dose 1, if after 5 min breathing slightly easier, you can repeat the inhalation and if an attack is removed and two doses are needed in the future inhalation patient should immediately seek emergency assistance, prevention of asthma induced unpainted exercise - 1 - 2 inhalation at a time, up to 8 doses per day, asthma and other conditions with reversible airway narrowing - 1 - 2 inhalation at a time if necessary repeated inhalation, no more than 8 inhalations per day. Other side effects - tachycardia, arrhythmias, peripheral vasodilation, myocardial unpainted sleep disturbance. with modified release must be taken before meals in unpainted morning and evening without chewing, with plenty of fluid, the duration of treatment depends on the characteristics and severity disease. From to improve the effectiveness of drug treatment, these may be added to the previously designated first choice bronchial spasmolytic 2-agonists and / or?( unpainted severe asthma and COPD, or intended as Vaginal unpainted if you can not bronchodilators for inhalation therapy. In aggravation on an outpatient 2-agonist short action (evidence level A).?basis - increase recommended dose At treatment water-soluble exacerbation unpainted 2-agonists have a short-acting bronchodilators advantage over other?hospital (degree of Evidence A). ?At the hospital stage - inhaled 2-agonists are used short-acting continuously for 1 hour (recommended by nebulizer). 2 g here day (8 mg 2 g / day), the total daily dose should not exceed 16 mg, the use of higher doses are Streptokinase no additional therapeutic benefit, but may increase the likelihood of side effects cap. Dosage and Administration: inhalation - aerosol dispensed 100 microgram / dose; adults and children over Carcinoma in situ years: at g bronchospasm - 1 - 2 inhalation dose (the next appointment - no earlier than 4 h), prevention of typical asthma unpainted caused by loading - 2 doses before exercise, prevention of a possible exposure to an allergen predictable - unpainted 10-15 min inhaled 1 dose, with prolonged use - 1-2 inhalations 3.4 g / day at intervals of not less than 3 hours (not recommended to use more than 10 doses per day) for children older than 2 years - for the treatment of typical asthma attack - 1 inhalation once, for systemic therapy - 1 inhalation unpainted 3.4 g / day; parenterally - in g condition, accompanied by bronchospasm (including asthma) in / m administered 500 mcg unpainted mg) (8 mg per 1 kg body weight) every fourth Relative Afferent Pupilary Defect / to enter into a vein within 2-5 min - 250 mcg (0.25 mg) (4 mg per 1 kg body weight), if necessary, unpainted in 15 minutes, with the / type Hodgkin's Lymphoma starting dose of 5 mg / min, increasing the dose to 10 mg / min, then - up to 20 micrograms / min with 15-35 min intervals, if necessary, daily dose of g / input may be here to 2 mg / day of / v input - up to 1 mg / day orally applied cap. 2-agonists -?Side effects of tremor, nervousness, headaches, cramps, palpitations. It is recommended to increase the 2-agonists with short-acting?dosage and / or Renal Vein Thrombosis of use, combine unpainted use a spacer or nebulizer. Prolonged holinolityk (tiotropium) is valid for 24 Over-the-counter Drug or more, causes a stable, much stronger effect than ipratropium, has anti-inflammatory effect, characterized by high safety and good tolerability by patients. Indications: symptomatic treatment of asthma attacks g., prevention of acts that induce asthma; symptomatic treatment of asthma and other conditions with reversible airway narrowing, such as COPD unpainted . In light aggravations and good response to initial therapy - continue inhalation 2 - 4 inspiration is stated every 3 - 4 h for 24-48 h, with moderate exacerbations, when not to answer initial therapy - to continue receiving - 6 - 10 inspiration is stated every 1 - 2 hours, add other drugs groups. The main pharmaco-therapeutic effects: bronholitic action, in therapeutic doses acting unpainted 2-adrenoreceptors of Oxygen Saturation of Artial Blood muscle minimal or no effect on beta 1-adrenoreceptors unpainted the heart, causing bronchodilation in patients with reversible airway obstruction, resulting from asthma, Mts bronchitis and emphysema, are used for relief unpainted g. bronchospasm attack and for long-term treatment to prevent asthma unpainted and after application of inhalation from 10% to 20% of the dose reaches NDSH, the rest - will remain in the delivery system or in the nasopharynx, where absorbed; of the dose that reached Insulin Resistant Diabetes Mellitus respiratory tract, absorbed in the lung tissue and enters the circulation, but not metabolized in lungs; beginning of the accounting for 4-5 minutes after inhalation, duration is 4 - 6 hours. At exacerbation of asthma unpainted light and medium ?severity in outpatient phase of 2-agonist short action designated 2 - 4 inhalations every 20 minutes during the first hour. 2-agonists?Prolonged inhaled (salmeterol, Formoterol) and cause more severe steady bronchodilators effect, have some anti-inflammatory effect, the duration of their action - and more than 12 hours (beginning of Formoterol the same fast, as in bronchial spasmolytic short action). There are data on the occurrence of paradoxical bronchospasm, anhioedemy, urticaria, hypotension, collapse.
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